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Nortriptyline For Migraines: An Alternative Prophylactic

Nortriptyline is a tricyclic antidepressant (TCA) that was initially FDA approved in 1964 (under the brand name “Pamelor”) for the treatment of major depression.  It is regarded as chemical successor to Amitriptyline based on the fact that Nortriptyline is Amitriptyline’s predominant psychoactive metabolite.  Since Nortriptyline has been on the market since the mid-1960s, researchers are …

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How Long Does Nortriptyline Stay In Your System?

Nortriptyline (brand name “Pamelor”) is considered the chief pharmacologically active metabolite of the chemical amitriptyline, a tricyclic antidepressant derived from dibenzocycloheptene.  Formation of nortriptyline occurs upon hepatic oxidative N-demethylation of amitriptyline via CYP2D6 and CYP2C19 isoenzymes.  In the early 1960s, researchers realized a significant portion of amitriptyline’s antidepressant effects resulted from the formation of its …

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Nortriptyline Withdrawal Symptoms + Duration

Nortriptyline (Pamelor) is a tricyclic antidepressant that is commonly used as a second-line treatment for major depression.  It is also sometimes prescribed for conditions such as chronic fatigue syndrome, bedwetting in children, migraine headaches, and neuropathic pain.  The drug may also be effective for some individuals in managing symptoms of attention-deficit hyperactivity disorder (ADHD). This …

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Tricyclic Antidepressants List (TCAs)

Tricyclic Antidepressants (TCAs) were developed in the 1950s as a way to treat depression with chemical compounds. These drugs are known for their specific chemical structure consisting of three rings of atoms, hence being referred to as “tri”-cyclic. Tricyclics were developed after researchers began exploring derivatives of the first typical antipsychotic medication Thorazine. Experimentation with derivatives …

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