Ibogaine is a psychoactive indole alkaloid derived from plants of the Apocynaceae family, including: Tabernanthe iboga, Voacanga africana and Tabernaemontana undulata. When ingested by humans, ibogaine induces a psychedelic response with dissociative and opioidergic properties. The [subjective] experience of ibogaine is often described as biphasic such that the first phase (4 to 6 hours) is …
Kratom (Mitragyna speciosa) is an evergreen tree from the Rubiaceae (coffee) family that produces leaves containing numerous psychoactive compounds, most notably including indole alkaloids: 7-hydroxymitragynine, mitraphylline, and mitragynine. When ingested by humans, the aforestated indole alkaloids significantly modulate CNS activity primarily via partial agonism of mu-opioid receptors (MORs). In addition, evidence from pharmacodynamic investigations suggests …
It is estimated that over 50% of all individuals in the U.S. aged 18+ have consumed an alcoholic beverage within the past month. Approximately 70% of people have consumed alcohol within the past year. While many people seriously enjoy drinking in social situations and “going out” with friends to bars on the weekends, others find …
Abilify (Aripiprazole) is an atypical antipsychotic drug that is commonly used to treat severe psychiatric conditions like schizophrenia and bipolar disorder. In recent years, it has been heavily marketed as an antidepressant augmentation strategy. Despite the fact that this has been one of the most profitable medications of recent years, some research has suggested that …
Wellbutrin (Bupropion) is considered an atypical antidepressant and smoking cessation aid that was first approved for medical use in 1989. It functions different than most antidepressants in that it inhibits the reuptake of stimulatory neurotransmitters norepinephrine and (to a lesser degree) dopamine. Its action as an NDRI drug generally results in increased energy, focus, and …
Seroquel (Quetiapine) is a popular atypical antipsychotic medication that has been approved by the FDA to treat schizophrenia, bipolar disorder, and as an antidepressant augmentation strategy in cases of refractory depression. Due to the variety of conditions for which this drug is prescribed, it is considered highly profitable and has made AstraZeneca (the developers) billions …
Remeron (Mirtazapine) is an atypical antidepressant that is technically classified as an “NaSSA” (noradrenergic and specific serotonergic) drug. It is considered a highly effective antidepressant, and some have posited that Remeron is superior in efficacy compared to other antidepressants. In a meta-analysis from 2009, it was found to be more effective than all SSRIs, SNRIs, …