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30+ New Antidepressants (2018): Drugs In Clinical Trials

Research suggests that upwards of 16 million American adults (6.7% of the adult population) are afflicted with major depressive disorder (MDD), a neuropsychiatric condition characterized by overwhelming sadness, behavioral changes, sleep disturbances, and cognitive deficits.  As of current, depression is the leading cause of disability in the United States among individuals between the ages of …

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Intermittent Explosive Disorder (IED): Causes, Symptoms, Treatment

Intermittent explosive disorder (IED) is regarded as a subtype of impulse control disorder characterized by impulsive, uncontrollable explosive outbursts of anger, aggression, and/or rage – sometimes accompanied by violence.  To be considered intermittent explosive disorder, the explosive outbursts of anger must be triggered in situations and/or conditions in which such anger is unjustified.  In other …

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Antidepressant Trials May Exclude Over 82% of People with Depression

A recent publication in the Journal of Psychiatric Practice documented that nearly 4/5 individuals diagnosed with major depression are considered ineligible to participate in clinical trials for new antidepressant drugs.  This means that for every 5 individuals with depression that attempt to join an antidepressant clinical trial, only one will meet inclusion criteria for registration.  …

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Post Acute Withdrawal Syndrome: Causes, Symptoms, Treatment

Individuals that have used any potent drug, particularly for a long-term and/or at high doses are known to experience significant short-term withdrawal symptoms.  These symptoms may include things like dizziness, headaches, nausea, and vomiting.  Over time, they usually lessen in severity as the nervous system and physiology adjusts to function without the presence of the …

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Provigil (Modafinil) For Depression: An Effective Off-Label Treatment

Provigil (Modafinil) is a eugeroic drug that was originally approved in 1998 for the treatment of excessive daytime sleepiness associated with narcolepsy, shift work sleep disorder, and obstructive sleep apnea.  Despite never attaining FDA approval for the treatment of depression, many anecdotal reports highlight the efficacy of Provigil as an antidepressant.  The drug tends to …

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